Pharmacokinetic and Pharmacodynamic Effects of Intranasal Epinephrine Versus Intramuscular Epinephrine in Adults

Autoinjectors Preferred for Intramuscular Epinephrine in Anaphylaxis and Allergic Reactions

INTRODUCTION Epinephrine is the treatment of choice for anaphylaxis. We surveyed emergency department (ED) healthcare providers regarding two methods of intramuscular (IM) epinephrine administration (autoinjector and manual injection) for the management of anaphylaxis and allergic reactions and identified provider perceptions and preferred method of medication delivery. METHODS This observati...

Iv. Response of Citric Acid Levels of Normal Adults and Children to Intramuscular Injection of Epinephrine.

Vasopressin and epinephrine versus epinephrine in management of patients with cardiac arrest: a meta-analysis

Objective. A combination of vasopressin and epinephrine may be more effective than epinephrine alone in cardiopulmonary resuscitation (CPR), but evidence is lacking to make clinical recommendations. This meta-analysis compares the efficacy of vasopressin and epinephrine used together versus epinephrine alone in cardiac arrest (CA). Methods. We searched MEDLINE and EMBASE for randomized trials c...

Effects of Racemic Epinephrine Inhalation

Epinephrine inhalation is now widely used to provide bronehodilator therapy for patients with chronic obstructive pulmonary emphysema. In this study a variety of cardiorespiratory effects following epinephrine inhalation have been examined to compare responses in normal and emphysematous subjects, and to evaluate possible differences between inhalational and parenteral usage of the drug. Since ...

Cardiovascular effects of epinephrine and dipivalyl epinephrine applied topically to the eye in patients with glaucoma.

The cardiovascular effects of topical ophthalmological preparations of 2% epinephrine (EPI), 0.1% dipivalyl epinephrine (DPE), and placebo were studied in double-blind fashion in 20 patients with glaucoma. Both drugs and placebo produced a decrease in heart rate (2 +/- 3 beats/min) which, although small, was highly significant (p less than 0.001). Neither drug not placebo produced a significant...